The reunion that almost was
Longtime Grey’s fans still get misty about those early seasons — and who can blame them? McDreamy and McSteamy were peak TV heartthrob energy. Patrick Dempsey just revealed he and Eric Dane had actually talked about teaming up again for his new show, but the plan never came to pass.
ALS changed the script
Dempsey says he’d been in touch with Dane and that they tried to arrange a cameo, but the progression of Dane’s ALS made it unrealistic. It’s a bittersweet update: the idea was there, the chemistry presumably would’ve been, but real life intervened.
Dane’s been busy — and brave
Even with the diagnosis, Dane hasn’t disappeared. He’s been taking roles on shows like Countdown and Euphoria, and he popped up in an episode of Brilliant Minds where his character faces an ALS diagnosis. Cast and crew reportedly reacted to his performance with a heartfelt standing ovation and a long round of applause.
Respect from an old friend
Dempsey spoke warmly about Dane, praising his courage, humor, and smarts. He said he checks in with him and admires how Dane is using his platform to raise awareness about the disease. The tone was equal parts admiration and heartbreak — for Dane and for his family.
Footnotes from Grey’s history
For context, Dane arrived on Grey’s in Season 2 and left in Season 9, while Dempsey’s Derek Shepherd was a major presence through Season 11. Their characters’ exits remain two of the show’s most emotional moments, and fans still talk about them.
Missed appearances and the ripple effects
Dane also missed a planned Emmy appearance last year after a fall, and a tribute segment ended up featuring other Grey’s alums in his stead. Small reminders that health can shift plans quickly, even for big TV moments.
Where to catch the shows
Dempsey’s new crime series airs on Fox and becomes available to stream the next day on Hulu. If you’re feeling nostalgic, Grey’s Anatomy’s full run is available to binge on streaming platforms, so you can relive the McDreamy/McSteamy era in all its melodramatic glory.
The takeaway
It’s a gentle, slightly sad reminder that reunions don’t always happen — but the fact that the two actors were in touch means a lot on its own. Fans can keep hoping, keep streaming, and keep sending love to Eric Dane as he continues to work and raise awareness about ALS.